Here is a summary from *Pediatr Clin North Am* - 01-DEC-2007:
Savino and colleagues
evaluated the effect of
*probiotics* and prebiotics on *colic*. In one trial, they compared a *
probiotic* (*Lactobacillus reuteri*) with simethicone in a randomized
controlled trial in 90 exclusively breastfed colicky infants. Simethicone, a
conventional nonprescription medication, has been previously shown to be
ineffective for *colic* treatment
After the 1-month trial, 95% of the *probiotic* treatment group responded
(no longer met Wessel criteria for *colic*) versus only 7% of the
simethicone group. The second study randomized 267 formula-fed infants to
one of two arms
The treatment group was fed a novel partially hydrolyzed whey protein
formula supplemented with prebiotic oligosaccharides and the control group
received the standard formula (without prebiotics) and simethicone. The
treatment group, after both 1 and 2 weeks, had a significant reduction in
crying episodes when compared with the control group.
With regard to the immune compromised patients, how do the European
reports define "immune compromised?" Certainly any neonate/young infant can
be technically be defined as "immune compromised" or "immunologically
immature" but I would think giving probiotics to a healthy 6 month old is
different than a 16 year old with ALL undergoing chemotherapy and an ANC of
I have never personally recommended probiotics or yogurt to parents in the
ED, but find the possibility of giving this advice intriguing, especially
when I have little else to advice these understandably beleaguered parents.
John Lee, MD
On 2/20/08, Michael Gorn <[log in to unmask]> wrote:
> Check out this recent study in Pediatrics. There is
> some helpful info there as well.
> Francesco Savino, MD, Emanuela Pelle, MD, Elisabetta
> Palumeri, MD, Roberto Oggero, MD and Roberto Miniero,
> MD Lactobacillus reuteri (American Type Culture
> Collection Strain 55730) Versus Simethicone in the
> Treatment of Infantile Colic: A Prospective Study
> PEDIATRICS Vol. 119 No. 1 January 2007, pp. e124-e130
> --- "D. Scott Moore, DO, MS" <[log in to unmask]>
> > A follow up....
> > Has anyone actually looked at this? I know not
> > exactly an emergency
> > medicine topic, but I have fielded many questions at
> > night about this. I
> > wonder how good this work is?
> > Scott
> > On Tue, Feb 19, 2008 at 9:54 PM, D. Scott Moore, DO,
> > MS <[log in to unmask]>
> > wrote:
> > > I have a friend who has a colicky baby and was
> > trying to counsel him.
> > > Have any of you heard of research using probiotics
> > (Yogurt or Acidophilis)
> > > for treatment of colic? He had asked me what I
> > thought about it. Can
> > > anyone anticipate any problems giving a 6 week old
> > baby with colic a
> > > probiotic? I wonder if a pacifier or nipple with
> > a tiny bit of yogurt on it
> > > would facilitate gut colonization with good
> > bacteria.
> > >
> > > What do all of you tell frustrated fatigued
> > parents?
> > >
> > > Scott
> > >
> > > D. Scott Moore, D.O., M.S., F.A.A.E.M.
> > --
> > D. Scott Moore, D.O., M.S., F.A.A.E.M.
> > For more information, send mail to
> > [log in to unmask] with the message: info
> > PED-EM-L
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