The studies I have on hand for epi in bronchiolitis are the following:
Menon K. J Pediatr 1995;126:1004-7.
Sanchez I et al. J Pediatr 1993:122:145-51. (The famous 'sedate
bronchiolitics with chloral hydrate and do PFTs study')
Kristjansson S et al. Arch Dis Child 1993;69:650-654.
Reijonen T et al. Arch Pediatr Adolesc Med 1995;149:686-692.
There's lots of data on injectable epi for bronchiolitis from the 70s. When
studying bronchiolitis however, I always
remember two studies that put it all in perspective:
Kong XT et al. Treatment of acute bronchiolitis with Chinese herbs. Arch Dis
Child 1993;68(4):648-71. - Single blinded
study showed a 25% reduction in the number of days with cough - let's see
xopinex do that!!
Wang E. et al. Observer agreement for respiratory signs and oximetry in
infants hospitalized with lower respiratory
infections. Am Rev Respir Dis 1992;145:106-109. - Observers assessed four
clinical signs - the agreement beyond chance for all four
clinical signs was below 50% (kappas ranged from .25 to .48).
to wit: how can we agree which drug is best when we can't agree on which
patient is better?
Jay Fisher MD
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