Am J Hosp Pharm. 1984 Feb;41(2):300-2.
Shelf life of unrefrigerated succinylcholine chloride injection.
Boehm JJ, Dutton DM, Poust RI.
The shelf life of succinylcholine chloride injection at several pH values
stored at room temperature was evaluated. Solutions containing 20 mg/ml of
succinylcholine chloride were stored at 25 and 40 degrees C. The reaction
studied at pH values ranging from 3.0 to 4.5. At two-week intervals, the
solutions were assayed by high-pressure liquid chromatography. The initial
amount of succinylcholine chloride in all samples was 100.1 +/- 2.37% of
claim. Hydrolysis of succinylcholine chloride in unbuffered solutions
apparent zero-order kinetics. The pH range of maximum stability was found to
from 3.75 to 4.50. Succinylcholine chloride decomposed at a considerably
rate at 40 degrees C. Allowing for the effects of pH adjustment during
manufacture and degradation during shipping, losses of 7.0% and 9.0% potency
be expected after storage at 25 degrees C for four and six weeks,
Succinylcholine Chloride Injection, USP, should be stored in the
if unbuffered succinylcholine chloride injection complying with USP pH
must be stored at room temperature, it should not be kept for longer than
PMID: 6702837 [PubMed - indexed for MEDLINE]
Chemical stability and adsorption of succinylcholine chloride injections
disposable plastic syringes. [J Clin Pharm Ther. 1994] PMID:7962223
Stability of succinylcholine chloride injection. [Am J Hosp Pharm. 1991]
Stability study of epirubicin in NaCl 0.9% injection. [Ann Pharmacother.
Stability of revex, nalmefene hydrochloride injection, in injectable
solutions. [J Pharm Biomed Anal. 1996] PMID:8933423
Stability of cefazolin sodium in various artificial tear solutions and
aqueous vehicles. [Am J Hosp Pharm. 1987] PMID:3687969
On 3/21/07, Evan Mahl <[log in to unmask]> wrote:
> Dear Colleagues,
> Does succ really need to be refrigerated? The anesthesiologists at my
> institution keep succ in their "box" at room temp and don't seem to have any
> problems. While it is true that the label on the bottle recommends a
> storage temp of 2 to 8 Celsius, practice does vary.
> Evan Mahl, MD
> Kings County Hospital Center
> Brooklyn New York
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Emergency Medicine Residency
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