Late to this discussion...
Keflex for UTI?
Keflex is a first generation ceph, making it more appropriate for gram positives, not gram negatives.
Am I missing something?
(sent from mobile phone)
Division Chief, Emergency Medicine
Children's National Medical Center
From: "Bruce Nayowith" <[log in to unmask]>
Subj: Re; Keflex dosing
Date: Sun Jul 26, 2009 19:29
To: "[log in to unmask]" <[log in to unmask]>
Sorry about any misunderstanding. I am aware that Keflex is not Duricef. What I meant was that the Lilly folks tried to get out of the qid dosing with Keflex for ease of compliance once Duricef hit the market....
Here is a link to an Australian site (a quick Google search).
I did learn something from this - UTI can get bid dosing, and one shouldn't use bid dosing for over 1g total.
Here is their page 6:
DOSAGE AND ADMINISTRATION
KEFLEX is administered orally.
Adults The adult dosage ranges from 1 to 4 g daily in divided doses. The usual adult dose is 250 mg every 6 hours.
For streptococcal pharyngitis or tonsillitis, mild, uncomplicated urinary tract infections, and skin and soft tissue infections, a dosage of 500 mg may be administered EVERY 12 HOURS.
For more severe infections or those caused by less susceptible organisms, larger doses may be needed. If daily doses of KEFLEX greater than 4 g are required, parenteral cephalosporins, in appropriate doses, should be considered.
Twice daily dosing is NOT recommended when doses larger than 1 g daily are administered.
The usual recommended daily dosage for children is 25 to 50 mg/kg in divided doses. For streptococcal pharyngitis in patients over 1 year of age, tonsillitis, mild, uncomplicated urinary tract infection, and skin and soft-tissue infections, the total daily dose may be divided and administered EVERY 12 HOURS.
So, thanks for challenging my sources!
Take good care,
----- Original Message -----
From: "Richard Bartucci" <[log in to unmask]>
To: "Bruce Nayowith" <[log in to unmask]>
Sent: Sunday, July 26, 2009 6:42:04 PM GMT -05:00 US/Canada Eastern
Subject: Re: PED-EM-L Digest - 24 Jul 2009 to 25 Jul 2009 (#2009-167)
Keflex (cephalexin) is not the same molecule as Duracef (cefadroxil), and
does not have the same PK/PD profile.
Can you cite anything from treatment guidelines to support your contention
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