Any thoughts on this study? -Marc
Published online July 27, 2009
PEDIATRICS Vol. 124 No. 2 August 2009, pp.
Probiotic Effects on Cold and Influenza-Like Symptom Incidence and Duration in ChildrenGregory J. Leyer, PhDa, Shuguang Li, MSb, Mohamed E. Mubasher, PhDc, Cheryl Reifer, PhDd and Arthur C. Ouwehand, PhDe
a Department of Research and Development, Danisco, Madison, Wisconsin
b Department of Preventive Medicine, Medical College of Tongji University, Shanghai, China
c Department of Biostatistics, School of Public Health, University of Texas at Houston, Dallas Regional Campus, Dallas, Texas
d Department of Scientific Affairs, SPRIM USA, Frisco, Texas
e Department of Research and Development, Danisco, Kantvik, Finland
OBJECTIVE: Probiotic consumption effects on cold and influenza-likesymptom incidence and duration were evaluated in healthy childrenduring the winter season.
METHODS: In this double-blind, placebo-controlled study, 326eligible children (3–5 years of age) were assigned randomlyto receive placebo (N = 104), Lactobacillus acidophilus NCFM(N = 110), or L acidophilus NCFM in combination with Bifidobacteriumanimalis subsp lactis Bi-07 (N = 112). Children were treatedtwice daily for 6 months.
RESULTS: Relative to the placebo group, single and combinationprobiotics reduced fever incidence by 53.0% (P = .0085) and72.7% (P = .0009), coughing incidence by 41.4% (P = .027) and62.1% (P = .005), and rhinorrhea incidence by 28.2% (P = .68)and 58.8% (P = .03), respectively. Fever, coughing, and rhinorrheaduration was decreased significantly, relative to placebo, by32% (single strain; P = .0023) and 48% (strain combination;P < .001). Antibiotic use incidence was reduced, relativeto placebo, by 68.4% (single strain; P = .0002) and 84.2% (straincombination; P < .0001). Subjects receiving probiotic productshad significant reductions in days absent from group child care,by 31.8% (single strain; P = .002) and 27.7% (strain combination;P < .001), compared with subjects receiving placebo treatment.
CONCLUSION: Daily dietary probiotic supplementation for 6 monthswas a safe effective way to reduce fever, rhinorrhea, and coughincidence and duration and antibiotic prescription incidence,as well as the number of missed school days attributable toillness, for children 3 to 5 years of age.
Key Words: Lactobacillus acidophilus NCFM • Bifidobacterium animalis subsp lactis Bi-07 • antibiotic usage • upper respiratory infections • colds • influenza • probiotics
Abbreviations: CFU—colony-forming unit • OR—odds ratio
Danisco USA sponsored this study, employs 2 of the study authors, and has contracted 3 other authors regarding this study.
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