It has yet to be documented because we don't test routinely for Pen
resistance with GABHS. Our ID dept. now recommends using Cephalexin or
another ceph. if unable to clear Strep. from a symptomatic child using Pen.
Also, our micro lab is reporting that > 10% of pneumococcus isolates are
moderately resistant to pen and cephalosporins, thus requiring us to use
Vancomycin for serious infections.
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On Mon, 3 Jul 1995, Jim Lindsay wrote:
> On Mon, 3 Jul 1995, DAVID G. WARD (901) 572-3010 wrote:
> > Gilbert Z. Given,
> > <Where is the data for all this Pen-resistant Group A Streptococcus?
> > I'm not sure I specified GABHS. In Memphis we have, I think,
> > pneumococcus resistant to pen. I'll check with ID and get back to you
> > with more info. I'm out of town for the next week or so, though.
> I was just reading through the June 1995 Pediatric Clinics of North
> America titled Antimicrobial Resistance in Pediatrics. There is a
> chapter on Antibiotic Resistance in Group A Streptococci pp 539-551. They
> state "an isolate of GABHS that is resistant to penicillin has yet to be
> documented." The author goes on to state, "mutants exhibiting elevated
> MIC values for penicillin have been produced in the laboratory." So
> maybe it will just be a matter of time for this to occur, but it hasn't yet.
> Jim Lindsay, MD CAlifornia Pacific Med Center, San Francisco, CA