Yes, presnently there has been no GABHS resistant to penicillin. Penicillin
remains the treatment of choice. There is good data to support b.i.d. dosing
of children, 250 mg penicillin V in children under 12 and 500 mg in those
>On Mon, 3 Jul 1995, DAVID G. WARD (901) 572-3010 wrote:
>> Gilbert Z. Given,
>> <Where is the data for all this Pen-resistant Group A Streptococcus?
>> I'm not sure I specified GABHS. In Memphis we have, I think,
>> pneumococcus resistant to pen. I'll check with ID and get back to you
>> with more info. I'm out of town for the next week or so, though.
>I was just reading through the June 1995 Pediatric Clinics of North
>America titled Antimicrobial Resistance in Pediatrics. There is a
>chapter on Antibiotic Resistance in Group A Streptococci pp 539-551. They
>state "an isolate of GABHS that is resistant to penicillin has yet to be
>documented." The author goes on to state, "mutants exhibiting elevated
>MIC values for penicillin have been produced in the laboratory." So
>maybe it will just be a matter of time for this to occur, but it hasn't yet.
>Jim Lindsay, MD CAlifornia Pacific Med Center, San Francisco, CA
Gilbert Z. Given, M.D.
Associate Professor of Clinical Pediatrics
University of Chicago
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