I deleted a previous message where someone posed a question about the use
of Krazy glue (ethyl-2-cyanoacrylate) instead of Histoacryl Blue
(butyl-2-cyanoacrylate) for the repair of superficial lacerations. The
following reference may be useful:
Toriumi DM, Raslan WF, Friedman M, Tardy E. Histotoxicity of
cyanoacrylate tissue adhesives. A comparative study. Arch Otolaryngol
Head Neck Surg. 1990; 116:546-550.
This study was performed by ENT and plastic surgeons where they
performed bone grafts on the auricular cartilage of rabbits - comparing
the effects of the two tissue adhesives. They found that the
"shorter-chain" derivative (Krazy glue) was more toxic to the auricular
cartilage than was the "longer-chain" derivative (Histoacryl blue). "The
Krazy Glue-treated ears developed seromas with histologic evidence of
acute inflammation, tissue necrosis, and chronic foreign body giant cell
reaction. The Histoacryl-treated ears showed mild acute inflammation and
mild foreign body giant cell reaction".
However, it is unclear whether these results are applicable to the
scenario of superficial laceration repair.
Children's National Medical Center
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