-- [ From: Martin Herman * EMC.Ver #2.5.1 ] --
I did a medline search on GA-1 and found one reference::
Osaka H, Kimura S, Nezu A, Yamazaki S, Saitoh K, Yamaguchi S
Chronic subdural hematoma, as an initial manifestation of glutaric
aciduria type-1 [see comments]
Department of Pediatrics, Yokohoma City University School of Medicine,
Brain Dev 1993 Mar-Apr;15(2):125-7
Article Number: UI94027655
A 10-month-old male with glutaric aciduria type-1 (**GA-1**) is reported
. This patient showed frequent partial motor seizures, irritability, and
involuntary movements, including oral dyskinesia at the age of 3 months.
On admission, magnetic resonance (MR) scanning revealed a chronic
subdural hematoma and widening of the bilateral insular cisterns. Urine
organic acid analysis showed marked excretion of glutaric acid, 3-
hydroxy glutaric acid and glutaconic acid, suggesting **GA-1.** Removal
of the subdural hematoma was effective for the irritability but not for
the extrapyramidal signs. This is the first report of a subdural
hematoma as an initial symptom in a patient with **GA-1.** However, the
complication of subdural fluid collection in **GA-1** is not rare. To
our knowledge, of 29 patients with **GA-1** who underwent computed
tomographic or MR scans, 5 had subdural fluid collection.
Disproportional hypoplasia of the temporal lobes may be a suggestive
etiology of subdural fluid collection/chronic subdural hematoma.
Comment in: Brain Dev 1993 Nov-Dec;15(6):460-1
I also believe that MELAS can present with similar findings and also
someof the coagulopathies related to protein S or C .
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