I believe the sed rate is inaccurate in sickle cell patients due to the
abnormal shape of their red cells. This prevents the from being able to form
roulades(?sp) (coulumns of red cells). It is the formation of roulades which
allows red cells to "fall" quicker leading to a " higher" sed rate. Acute
phase reactants coating a persons red cells allows roulade formation by
decreasing, I believe, the normal negative charges on the red cell membrane
which normally prevents this from happening.
Of course I could be making all this up.
Jonathan Bennett, MD
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